Thermo Scientific Krios Cryo-EM
is a low-temperature transmission electron microscopy platform used to study the structure of biological macromolecules and complex assemblies.
What science makes it possible The
Vitrified preservation reduces structural changes caused by drying; multiple low signal-to-noise ratio projections are aligned, classified and reconstructed to recover three-dimensional information. The resolution is determined by the sample, imaging and calculation.
Understanding the product requires putting a single formula back into the system: input measurements, materials and boundary conditions are calculated by the model and then compared with actual data. Approximations at different scales cannot be unconditionally spliced, and relevant tools will indicate applicable conditions respectively.
Commercial applications and engineering boundaries
structural biology team uses three-dimensional density to explain the conformation of protein complexes, and then combines biochemical and functional experiments to verify the mechanism. The
is an independent technical interpretation based on the manufacturer's public information and does not represent the manufacturer's adoption, endorsement or sponsorship of SciAtlas. The illustrations are original illustrations of the principles of this site, not photos of the actual products. Product specifications, certifications and availability are subject to the manufacturer's current information; the relevant tools only demonstrate public simplified models.
Manufacturer’s products and official information ↗Use online tools to understand related issues
Protein Structure
PDB/mmCIF first model; alignment requires equal length according to Cα order, no sequence alignment is performed. The pockets are user-given residues and no binding sites are predicted.
FFT Spectrum
Real signal, uniform sampling, rectangular window; not power spectral density.
Singular Value Spectrum
Up to 400 elements, values close to zero are not automatically treated as exact zero.
Electron Wavelength
Non-relativistic electrons accelerate from rest, high voltage requires relativistic correction.
linked model is used for independent learning and magnitude analysis and does not copy the manufacturer's proprietary software or pass product performance certification.
People and historical contributions behind the science
The following relationships distinguish theoretical and method pioneers and industry leaders; it does not mean that these figures independently invented the product on this page.
won the 2017 Nobel Prize in Chemistry for developing sample vitrification methods in cryogenic electron microscopy.
Joachim FrankJoachim Frankdeveloped a single-particle electron microscopy image processing method and won the 2017 Nobel Prize in Chemistry.
Ernst RuskaErnst RuskaPioneer in the development of electron microscopes, he won the 1986 Nobel Prize in Physics for his work related to electron optics and the design of the first electron microscope. The short wavelength of
Related Elements and Materials Basics
elemental portal is for understanding related materials or molecular basis and does not claim a complete materials list for a specific model.