PHARMACOKINETICS & PHARMACODYNAMICS

primary elimination half-life

Convert linear elimination constants to concentration halving times.

t1/2=ln⁡2k=ln⁡2 VCLt_{1/2}=\frac{\ln2}{k}=\frac{\ln2\,V}{CL}

symbols, variables and units

k:h⁻¹;V:L;CL:L/h;t_1/2:h。

applicable conditions and boundaries

One-chamber one-stage elimination; non-linear process half-life may vary with concentration.

formula source code

The following is a copyable LaTeX expression.

t_{1/2}=\frac{\ln2}{k}=\frac{\ln2\,V}{CL}

Reference and Extended Learning

NCBI Bookshelf · Pharmacokinetics ↗

is organized according to model definition and assumptions. Please check actual conditions and original literature before engineering, research and clinical use.

half lifehalf-life

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