Leonor Michaelis
Leonor Michaelis
main contribution
worked with Maud Menten to establish classical enzyme kinetic relationships, influencing biochemical and pharmacokinetic saturation analyses.
Biographical or institutional source material ↗’s relevance in technology cases
The following cases cite their theories, methods or industry contributions; the historical basis does not mean that I directly participated in or invented modern products alone.
Certara Phoenix pharmacokinetic analysis platform Interdisciplinary principle illustration of the ↗
concentration-time data can be used to estimate exposure, clearance, and half-life; sampling design, terminal slope selection, and missing data rules can affect results.
GastroPlus physiological pharmacokinetic simulation Illustration of the interdisciplinary principle of ↗
Mass conservation and differential equations for tissue absorption, distribution and clearance processes; extrapolation of in vitro parameters to in vivo requires assumptions, calibration and external data verification.