PK Simulator: uses and methods
interactively explores the effects of dose, clearance, and dosing intervals on exposure.
Applicable scope and calculation boundary
linear one/two-compartment model supports bolus injection, constant-rate infusion, and first-level oral absorption; for research and teaching purposes. Steady-state peak-trough single-compartment bolus provides analytical results.
model and reference method
Atrioventricular ordinary differential equations; linear superposition and piecewise integration.
model version: 1.0.0. The results are used for scientific research, exploration and teaching, please interpret according to the model conditions.
input parameters
- Model
- One compartment / Two compartments
- Route of Administration
- IV bolus / Oral / IV infusion
- Dose（mg）
- Value range: 0.01 – 10000
- Dosing interval（h）
- Value range: 0.5 – 168
- Clearance CL（L/h）
- Value range: 0.01 – 1000
- Central volume V（L）
- Value range: 0.1 – 10000
- Dosing times
- Value range: 1 – 60
- absorption rate ka（h⁻¹）
- Value range: 0.01 – 20
- Bioavailability F
- Value range: 0.01 – 1
- infusion duration（h）
- Value range: 0.1 – 24
- intercompartmental clearance rate Q（L/h）
- Value range: 0.01 – 100
- Peripheral chamber volume（L）
- Value range: 0.1 – 1000
How to use
- Load the example or enter data that matches the field description.
- Confirm units and models, run calculations and check diagnostics.
- Export charts, tables or results packages and record model versions.
tools in the same field
are free and open; free sponsorship does not affect tool permissions. All functions of Read scientific methods and data explanations 。