Lewis Sheiner
Lewis Sheiner
main contribution
An important promoter of population pharmacokinetics and pharmacometrics, involved in the development of NONMEM methods and software.
Biographical or institutional source material ↗’s relevance in technology cases
The following cases cite their theories, methods or industry contributions; the historical basis does not mean that I directly participated in or invented modern products alone.
Certara Phoenix pharmacokinetic analysis platform Interdisciplinary principle illustration of the ↗
concentration-time data can be used to estimate exposure, clearance, and half-life; sampling design, terminal slope selection, and missing data rules can affect results.
NONMEM population pharmacokinetic modeling ↗
Fixed effects describe the overall trend, and random effects describe individual and residual variation; parameter identifiability, covariate selection, and diagnosis are crucial to model interpretation.