Frederick Sanger
Frederick Sanger
main contribution
made important contributions to protein and nucleic acid sequence analysis and won the Nobel Prize in Chemistry twice.
Biographical or institutional source material ↗’s relevance in technology cases
The following cases cite their theories, methods or industry contributions; the historical basis does not mean that I directly participated in or invented modern products alone.
Illumina NovaSeq X Sequencing System ↗
sequencing reads need to undergo quality assessment, comparison and statistical analysis; coverage depth, error probability and sample bias jointly affect the variation evidence, and the number of original bases is not equivalent to the amount of effective information.
Oxford Nanopore PromethION ↗
molecules cause current changes through the pores, and the algorithm interprets the time signal as a sequence; read length, error characteristics, modification identification and sample processing are interrelated.