Jacques Dubochet
Jacques Dubochet
main contribution
won the 2017 Nobel Prize in Chemistry for developing sample vitrification methods in cryogenic electron microscopy.
Biographical or institutional source material ↗’s relevance in technology cases
The following cases cite their theories, methods or industry contributions; the historical basis does not mean that I directly participated in or invented modern products alone.
Thermo Scientific Krios Cryo-EM ↗
Vitrified preservation reduces structural changes caused by drying; multiple low signal-to-noise ratio projections are aligned, classified and reconstructed to recover three-dimensional information. The resolution is determined by the sample, imaging and calculation.